Take a look at what Buffalo Bore offers and you can see what's possible out of certain rifles and revolvers.
http://www.buffalobore.com/ammunition/default.htm
What you don't want to do is hot load the .45 LC and shoot it through a firearm that just won't handle the pressure.
Buf-Bore now makes standard pressure loads for even the modern Colt clones. (200gr. Speer Gold Dot, 1100 fps M.E. 537 ft. lbs)
Or, for certain large framerevolvers and all model 1892's and all Winchester or Marlin 1894 models;
325 gr. cast bullet (1325 fps /1267 ft. lbs/big game up to 1,000 pds.)
260 gr. J.H.P. (1450 fps / M.E. 1214 ft. lbs./Big game up to 350 lbs.)
Those number were derived from pistols, so you can reasonably add 150-200 fps, maybe more, when using them through a rifle.
Hope this helps, and take a look at the loadswap section too.