Yes.
There can be different causes, including powder contamination, but the most common is the powder being used is too slow for the bullet weight. If a light-for-powder-bullet gets a good initial start down the tube, say, from a slightly warm primer, the portion of the powder that starts burning at first, near the primer, can fail to evolve gas fast enough to keep up with the bullet and maintain burning pressure. So instead, pressure drops rapidly and the bullet actually starts slowing down in the tube.
In a bottleneck case, typically about 50% of the powder is pushed down the tube with the bullet by the initial pressure and continues to light up as the pressure and heat reach their peak. But if the bullet gets going too fast for the powder, that peak is not reached before the 50% or so of the powder is spread out in the tube making it hard for one grain to light the next. And if the bullet the muzzle before it gets lit, it never does. Bottom line is a low pressure trip down the tube and much lower than normal muzzle velocity.
There are other problems with using a powder that is slow for the bullet weight, including having the bullet slow so the unburned powder mass rear-ends it further down the tube. That causes the bullet to upset and hammer the barrel radially. This can cause a barrel bulge and, in the worst case, actually blow the end of the barrel off. Texas gunsmith Charlie Sisk had some photos of this which he has been able to replicate on demand with some .338's (I forget if it was the Lapua Mag or some other?).
You can see those powder rear-end collisions with the bullet if you have a strain gauge instrument on your rifle chamber. They cause it to appear there is a secondary spike in pressure after main powder pressure peak, though it is actually just the traveling expansion wave from the radial impact. This is known because, even when the barrel is blown off by an extreme case, the case typically looks like it fired a low pressure load; nicely rounded primer, no brass expansion or sticky bolt events.
RSI has pressure traces showing these pretty clearly if you scroll down to the third from last and the last traces,
here. I'd like to slug the barrel of a rifle that's been shooting those loads for a long time. It would be interesting to see if a loose spot has been formed in the bore.
So, bottom line, what is your load?