Well, true re: the bench rest crowd, but they are often on the edge of stability. I've read of groups going sour during a match due to extreme weather. So, it's an issue for them, but not so much for the rest of us mere mortals. Our off-the-shelf guns almost always have plenty of extra twist that conditions don't cause a problem in regards to that.
The main point of the OCW method is to try and find a charge weight that is fairly insensitive to conditions. You would want to fire all of the groups on the same range outing if possible. That should eliminate conditions as a variable. When you pick a load in the middle of a range of several charges that are all consistent, then that load should be fairly insensitive to ordinary weather fluctuations.
Having said that, if you do the work in the middle of summer and hunt in the dead of winter, it might be good to check the results as close to hunting conditions a possible. Or, better, do the load work up in close to expected conditions.
But a change of a few percent in humidity or 20 degrees in temp shouldn't put things in the ditch. If it does, then something else is wrong. Or, you have a very specialized setup as per the first paragraph.