QuickLoad suggests exactly what Mike already said: H380 is too slow, even with a 110% compressed charge, and IMR-4227 reaches max pressure with about a 90% charge. You might use IMR-4227 with the lightest bullets, in the 223Rem, but it's still a tad faster than what you'd want. Both are definitely too slow for the 45ACP but H380 is excellent for the 22/250 and the 4227 could be pressed into service, again with smaller (40gr) bullets.