Stretch, you make a very good point; most guns never get shot anywhere near enough to actually worry about the barrel or even the throat. When you consider how many accurate used guns, some of them 30, 40, 50 years old, are sitting on gun-store shelves, it's kind of funny that the casual shooter or hunter would hesitate to buy a given cartridge because it's a "barrel burner". 
The one exception I would make to this is the dedicated varmint hunter, shooting a 22-250, 220 Swift or 22 WSSM. Any of those could be shot > 500 times per year and lose the accuracy required for hitting very small targets, at long range. For big game cartridges from the .243 on up, odds are they'll never be shot enough to worry about it.
The one exception I would make to this is the dedicated varmint hunter, shooting a 22-250, 220 Swift or 22 WSSM. Any of those could be shot > 500 times per year and lose the accuracy required for hitting very small targets, at long range. For big game cartridges from the .243 on up, odds are they'll never be shot enough to worry about it.