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my experience with Saeco 300 grainer

Ive found the H110 meters beautifully and is accurate in my Colt Anaconda and my Rossi mod 92. Both being 45 Colt. The load that works for me the best is H110 20 grains behind the 300 gr.
For my standard loads in my S&W mod 25s I use a 255 gr Saeco using 9.5 to 9. grains of Unique.
I've not found the 'dirt' from Unique to be a problem. I may clean my Smiths after every thousand or so rounds. I wipe off the exterior with a rag, before I put the handgun in its rug, but that's it.
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