I am using 25 grains of H110 behind the RCBS 270-SAA. Mine weigh 284 grains from the mould, this load has worked quite well for me. I should mention that I started at 23.5 grains, and worked up. I am shooting these from 3 different Rugers, A NM Blackhawk I have had for quite a while, a SS Bisley Blackhawk, and a Super Redhawk 454/45.