An important aspect of the issue of H110 in the small case is the expansion of this stubby round. In the .40 S&W, the bullet doesn't have to move very far before the volume behind it doubles the volume the powder started burning in. When the burning space multiplies too rapidly, slow powder just can't double the gas volume fast enough to reach the desired pressure. The space quickly gets too big for the amount of powder the case can hold to ever get there at all.
H110/296 seems to want a powder column under the bullet of straight wall cases to be right around three quarters of an inches tall. At least, that's so for the .357 and .44 Magnums. I'll have to check, but presume it would apply in the .41 magnum, too. In the .357, for example, assuming the full 1.590" SAAMI maximum COL for all loads, that powder column height fills the power space 100% behind a 130 grain bullet. That produces roughly maximum muzzle energy for that powder in that cartridge. Going to a 110 grain bullet you get less ME as the bullet is too light to offer as much inertial resistance as the powder wants to build pressure against. Going to a 158 grain bullet shortens the powder column too much, causing the expansion problem to come into play, so, again, the maximum ME is lower than for the 130.
Anyway, you can't get a powder column that high in the .40 S&W, so efficiency isn't good.
Mike, are you aware you don't need to tweak the powder to fill the case in QuickLOAD? Just type 100 into the case fill percentage window directly. The software will figure out the needed charge weight.