I am reloading 300 Winchester Magnun for Hunting. In the past, I have always used IMR 4350 for the powder with a 200 grain Nosler Partion Spitzer (did I name this right/)bullet. This combination produced 2750 mfps, if I use IMR 4320 I would lose 250 mfps but save 12 grains of powder per round. With an eight pound can that is 201 more reloads or ten boxes of ammunition. Which is better, is there a clear cut answer ?