I have been experimenting with cast bullets in a .308 for several years and tried several powders. I finally settled on SR4759 because it has worked as well as anything else and is in general, a bulky powder that fills the case from 2/3 to 3/4 for any load I use.
I am still working on bullet weights. I have molds (all Lee) for 160, 180, and 200 grain that are round nose, plus a 150 grain flat nose. I have worked mostly with the 160, 180, and 200 bullets lately using a 50-50 mix of linotype and plumbers lead. With that alloy, I drop 157, 175, and 196 grain bullets. I seat them so the bottom of the gas check is at the base of the case neck and have had no problem chambering even the long 196 grainer. I have had no leading problem either. Have shot them extensively in both a Savage Weather Warrior and a Ruger Hawkeye, both with 1 in 10 twists. My best accuracy has been with the 157 grain bullets with occasional groups for 3 shots being around a half inch. I have another big test I will be doing in the next couple of weeks with 10 shot groups to verify some earlier results.
I am using from 24 to 27 grains of SR4759 and get around 2000 fps, depending on bullet and powder charge combination. I will post results when they come in in the bullet casting section.