Amen on the 358Win chambered in a Rem 750The Remington 750s are rated for any factory ammo made. The thing that harms semi-auto rifles is the powder burn rate. The 358 and 35 Whelen like faster powders, so you could shoot any good handload in a Remington 750 and not harm the Whelen. The 270 and 30'06 are a bigger worry for 750 handloaders than the Whelen. They like slow burning powders, and that kind of powder wrecks gasport systems in a hurry. If you want a serious critter thumper, then the Whelen in a Remington 750 is the why to go. I wish Remington would offer a 358 in the 750, I'd buy one tomorrow.