To be completley honest with you I realy don't think it matters what caliber you go with. 9mm 40 cal S&W .357 sig .45acp 10mm .38special .380 .357mag. or any others out their if you put a few in the boiler room well the job is done. Thousands of people have been shot and stopped or killed with all of them. Yes some will out proform others but the simple fact is shoot an inraged derranged crackhead lunitic in the chest 5 times with any of them chances are hes still going to come after you till he falls into circulatory failure which will can take 10-15 seconds even if thier heart is blowed up, or a round does enough dammage to their CNS to render em useless. Handguns suck at stopping people. With that said I still carry a handgun 24-7. They have their purpose and I would shoot that crackhead to protect myself but ya better expect to still fight or run. The nice thing about glocks and a few other manufactures is you can get a barrel swap for the .40 and .357 all ya got to do is change the barrel. So if you get one and think ya might like the other better just buy a barrel for 150 bucks or so and try the other. My work gun and EDC is a .40. If you serch the internet you will find hundreds if not thousands of articals stating that ya got to have a .357 or a .40 because the other one just plain wont work and bla bla. Ive fired both and like both calibers in question, but personaly Id go with the .40 and get the .357 barrel. .40 is alot easer to find and usually cheaper. I have shot wild pigs in Florida with both calibers. In all cases one shot to the heart lung area brought them down. I know many people do it but Im not suggesting going hunting with one of these. The pigs I shot where trapped and shot from a distance of about 10-15 feet. However I will admit that the .357 sig did seem to do a little more dammage but not a huge significant ammount and well the pig I shot with the .357 sig seamed to die a littel faster but I did not time it and any hunter will tell you for some reason some critters just dont know they are dead and run a zillion yards with a broken shoulder and no heart or lungs.