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The heaviest bullets I've used in the 375 Win are the 300gr from Mt Baldy. These have about the widest nose of any flat point bullet I've ever seen. It's been a while since I shot them and I don't recall the load but they were some serious thumpers. Even the light loads pushed back on the butt stock pretty hard. I believe these would be suitable for anything on this continent within 50 yd. Don't recall seeing anything as heavy as you mention before but I'd have to agree that case capacity would start getting shy. Loaded in 38-55 cases in a single shot might help that situation some.