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Whitesmoke, I've been using 50 grains of IMR 4198 in front of a 300grain remington @ 2100- 1"-1.5" groups(4X scope). I've loaded 55 gr. IMR 4198 300 rem. @ 2330fps. But case expansion is a little too much as is recoil in my handi-rifle. Hornady lists 53.3 grains (IMR 4198) for there 350gr. round nose in the Ruger#1.
As far as bullets go, you can buy 100 rem 300gr. hp for what 50 cost from sierra or hornady, and they work just fine on deer.
By the way I use 42 gr H4227 300gr rem for 1500fps in my Magnum Research 45-70 7.5" barrel.

Rick

If it hops it drops, If it flies it dies!
 
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