You have to be careful of all data sources. Never use just one. That's why I used the Lyman manual data as a cross check. Not in HS-6, but for comparative pressure/velocity predictions from other powders.
The discussion of the reliability of the computer models gets played out periodically. Some don't trust them at all, but I've had some pretty spectacular correspondence form some the work with Quick Load. Especially with some chronograph feedback to tweak things a little. The thing I tell people is that data in a manual is fired in a real gun, but it isn't your gun, so YMMV. The computer can be tweaked to match your gun, specifically, but it isn't firing in a real gun, so, again, YMMV.
The plus side of manual loads with pressures listed is the pressure guns have minimum chambers, so you own gun's not likely to see higher pressure. The downside is that most are still the obsolete copper crusher barrels, which have been shown to give so much extreme spread in results for the same load, sometimes even just from changing the technician running the tests, that, as was concluded in Precision Shooting some years ago, it just isn't a terribly useful number. As you see the modern Piezo transducers gradually replace the old copper crushers, that should go away over time.