Kosh, that's a very good post. If you shoot the big stuff, 44-45 calibers, then the only two powders you really need are Herco and 2400. There are lots of other good powders around (I've had really good success with Silhouette), but these two oldies will get everything done, from 700-1500 fps, with very good to great accuracy. Herco is a little slower and a little bulkier and a little cleaner burning than Unique, all of which are good by me. It's also usually easier to find where I live, and cheaper too. 2400 is very accurate in all my revolvers, and makes a decent "download" powder for rifles as well.