I concur with Carpe Diem, concerning using something BESIDES H110/W296 for .45 Colt work-up.
I've WORKED-UP Ruger/TC-Only loads for my .45 Colt Red Hawk and, unless the shooter simply MUST have the very LAST micro-joule of ballistic performance from his reloads, I generally recommend the use of Alliant 2400 over H110/W296. The difference in performance between a hot .45 Colt loaded to max with 2400 vs. the same round loaded to the max with H110/W296 is likely discernible, neither by the shooter nor the intended target.
To me, the work-up in magnum pistols is much simpler and more forgiving if 2400 is used. Alliant lists one load using 2400 in .45 Colt, 15.4/2400/250gr. Speer LSWC, which gives 970 f/s from a 5.5" barrel. John Taffin also listes a a rather formidable-sounding 21.0/2400/260gr. LSWC load, that just exceeds 1400 f/s from a 4 &5/8" or 5.5" revolver barrel. With a 5.6gr range of charge weight between SAAMI max, up to a load that is probably crowding TWICE SAAMI M.A.P., there.is a WONDERfully large margin of charge weights with which the reloader can make pretty much exactly what they desire, without worrying about uneven ignition, muzzle-borne flame-balls, excess amounts of unburned propellants, aand all the rest.
The "reduce by no more than 3% from maximum" warnings associated with work-ups using H110/W296 leaves the handloader a very thin margin between "starting loads" and "maximum loads". If the shooter simply MUST have the most of their .45 Colt Ruger/TC, IMR-4227 will deliver similar ballistics, and gives a wider-than-3%-margin between starting & max loads.
Unlike Carpe Diem, I have no experience with LilGun, so I'm hesitant to say much about it. What I HAVE heard of it, is that it seems to deliver very uniform performance when properly worked up, but also has a tendency toward a very loud report, when loaded to max performance, engendering some of the gents who use it extensively to refer to the propellant as "LOUDgun".
Another "advantage" of 2400 is that, even in quite emphatic loads, rarely have I seen a recommendation to use Magnum Large Pistol primers in the load (I use Win LPs, which may confuse the issue). It seems I almost never find data using H110/W296 in magnum pistol loads without the recommendation that magnum pistol primers ONLY be used. I don't recall poor results with Standard Large Pistol primers igniting H4227, neither do I recall improvements in performance when the primer was swtiched to Magnum LP primers. I don't know how to guide you using L'ilGun in work-up, except to follow loading data to the letter, then perhaps try a few loads with the other type of pistol primer & check for changes.
Okay, end of Master's Thesis... Good luck & (as always) be careful.