Sorry to hear about your cancelled hunt Chris. Know how that is I cancelled a Caribou hunt in 99, my family also came first, or at least my youngest daughter. She was born shortly after that.
Well any way, I load a lot of 300 gr WFN at a very moderate velocity. They are loaded over 7.5 gr of Titegroup. They shoot very well out of a 4 5/8 Vaquero. I load them for a friend of mine who is a Rancher and spends most of his time on his horse. This load is controllable and not to loud to blow some ears, horses mostly. This load has been used to take Bear, Deer, Coyote, Cougar, Steers, etc. One Steer was taken head on between the eyes the bullet went down the neck about 16" breaking bones all the way. This was at 10 ft or so.
I can't prove this on paper but that bullet just flat out performs. Wouldn't think twice about taking Bruins with this....
Will