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Jim,
 Hodgdon's no. 26 manual shows data for HS-6 and HS-7 for the 300gr. bullet. I've not used either in my .454 but have had excellent results with both in .38 special, .41 and .44 magnums. I have found that the published velocities for Hodgdon's loads are a bit exaggerated when chronographed.
300 grain bullet:
     Starting Loads                            Maximum Loads
Powder  Grs.  Vel.    CUP        Powder  Grs.  Vel.     CUP
HS-6      15.0  1084  31100    HS-6      19.0  1450  46200
HS-7      16.0  1111  33400    HS-7      22.0  1501  50200
                                                Hope this helps
                                                    Dave
 
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