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Picked up some 270g Thunderheads, sized 452 at a gun show. The man who sold them to me said, other loaders had good luck with them in their leverguns using 23g of H110 or 296 with mag primers. Does this sound like a good starting load?
 

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Hi Smokeless Jim,

If it were me, I'd use a load of 25-27 grs. of 4227. In my experience, H110 & 296 are THE powders to use with 320+ grain bullets in the .45 Colt but over the years I have had several bloopers with the 250-275 gr. slugs using 26 gr. charges.  Bullets were tight in the case with a heavy crimp. I switched to 4227 with these bullets and have never looked back.  The extra bullet weight of the 320 gr. + projectiles helps the 296/H110 ignite more consistantly and I use them exclusively with these heavy bullets.

Good luck,
John
 

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I've found that 19.5 grains of H110 behind a 300 grain cast, gas checked, sized .454 Saeco bullet, using a Winchester LR primer to light it up, works nicely. I get a good clean burn, no leading, accurate as I want it to be.
Jim
 
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