I won't argue anything the other guys have said. However, the two most important factors in my experience are the rifle barrel (you can never get a bad barrel to shoot well, and I have owned some that were awful) and the bullet.
I have often seen accuracy go from sour to sweet by simply changing to another weight or style of bullet. Personally I don't do much experimenting with powder types and charges, and just pick a suitable powder for the caliber and a safe load that produces a reasonable velocity. Then, if I don't get good results, I try a different bullet and see if things get better.
Now, I am happy if a big game rifle shoots into an inch and a half or less, and most of the rifles I own these days will do much better than that. I want my varmint rifles to do less than MOA, and the 2 I now own will both do much less. But, as long as the rifle and load meet my minimum personal standard, I'm happy.
Also, I would never use a load that didn't function properly from the magazine. I have seen guys so obsessed with the hunt for accuracy that their ammo was unreliable in a hunt for game, because the bullets were seated out so far that rounds would jam in the magazine.
I imagine that I could tweak things like powder charge and seating depth, and experiment with all kinds of different primers and powders...but I never do.