djg,
What are you planning on using this for the most? Are varmints your main focus or squirrels? If you are looking for something all around, something a little slower like 22 Hornet or 218 Bee might be good medicine. Especially if your typical shooting ranges are 150-200 yards or include lots of edible critters. There are quite a few sporter weight rifles (without the big bull barrels) for toting through the woods chambered in these rounds. If this is going to be strictly targets and long range varminting, 223, 22-250, 220 Swift would all be great choices. Just about any of the major manufacturers make excellent heavy barreled bolt action varmint rifles, Ruger has the No. 1 single shot (my personal favorite), Browning was making a Mini version of the Model 71 in 218 Bee, I'm not sure if they still are, but reports were that it was a very accurate lever gun. Whatever your fancy is, there are some really excellent rifles, actions and cartridges out there. Just find something that suits you and your intended use. Good luck and let us know what you decide and how it performs. One of the most accurate rifles I have ever shot was a Ruger No. 1 in 220 Swift. It was really something.