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I use a lot of H110 loading big handgun calibers on my RL550B.  I find that the charge variance will be .2 grain from smallest to largest, with most of the charges in the middle where they are supposed to be.  Three things to look at.  First, you need to make sure you are moving the operating handle the exact same way every time, especially on the last little bit of stroke where you are seating the primer.  Second, you want to have it adjusted to where the charge bar is all the way back at the very bottom of the downstroke.  Third, how much wiggle do you have in your loading bench?  Any is too much, if it shakes or wiggles very much while the press is cycled you will not get consistent powder charges.
Good shooting
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