For myself, I'd try to limit it to 150 yards, 200 at the outside. Even when I'd pack a .338Win. Mag., I've never had to shoot an elk at over about 225 yards. I've got 30+ to my credit and most have been shot under 100 yards. See if Hornady has any information on a ballistic chart for them. It might be interesting as the big slugs aren't real flat shooting. RKBA!
Brian aka The .41 Fan
HAVE MORE FUN AND GET THE JOB DONE WITH A .41