I am working with the Beartooth 0.452" 345 grain gas check bullet in my 45 Colt. I am wondering if you expert shooters generally find that the most accurate load is the one with the lowest extreme spread. I have tried H110 powder at 21 up to 24.2 grains and the lowest ES was 52 fps. With Lil'gun from 22 to 23.5 grains the lowest ES was at 23.5 grains and was 30 fps for 5 shots (6 shot cylinder). The best group was with 22.0 grains of Lil'gun though (1.8" at 30 yards). I wonder though if the larger groups with more powder was just me. I am still not very good with the open sights. Incidentally 22.0 grains of Lil'gun gave 1200 fps and 23.5 gave 1300 fps. 24.0 and 24.2 grains of H110 gave 1205 fps. Thanks, Brian.