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What type of large animals??
A 45 ACP fails the energy test for legal hunting at least in some areas. Checking the regs about what's legal to use would be a good start.
If 357 is legal, it will work for deer size animals. Not a good choice for bear or elk. I know nothing about hogs.
As with all weapons, with a 357 you will have to know the weapon and get within the right range.
A 44 is a great choice for hunting, but not a great defense gun. Might be more than you want to shoot wherever you are in need and one in a size that you want to shoot isn't easy to conceal.
Hard to pick one handgun to fill both uses. Pack a 1911 for people, pick up a 44 for cirtters.
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