I would use a 375 H&H magnum myself, I`m a little prejudiced because I have a Ruger #1 in that cal. I would also use Win. fail safe ammo in 270 or 300 gr. weight. I have shot both of these loads through 30" of hard wood and the bullet kept on going![ like that little rabbit on tv ]. I don`t really see how an animal could stand up to that kind of a hit. Of course this is just my opinion, and you know how that goes. The last time I looked however the bore on my 375 still seemed kinda big.