It was said early on under this topic that you should choose accurate loads over fast ones.
But while I COMPLETELY agree, fast loads are not necessarily in-accurate.
That, along with safety is the point of , "working up" loads.
Beginning at or close to the recommended starting powder charges, and working up slowly tells you what the firearm likes or dislikes. IT may be the powder or the bullet or the amount of powder, but working up allows you to see just how your firearm is reacting to that powder and increases in pressure.
Many folk say that they always find loads lower then the Max. listed loads to be more accurate, but over my years of reloading and testing, I have found the most accurate load with a given powder to be at or close to max as often and not.
I have seen groups shrink as pressures increase and then began to open up again, and seen loads simply not show anything good until I reached max.
WE can't know without testing each and every firearm and possibly a number of powders and bullets.
Yes, starting with a powder shown to give good results in the loading manuals is a good way to go. 4350 with a 165gr bullet in a 30/06 for example, but I have test loads ready to be tested in a new RUGER American "06", loaded with RL 22. Will I end up back with 4350, can't say until the testing is over.
Crusty Deary Ol'Coot
Well, I finally stepped up to the reloading plate and ordered a new RCBS Rockchucker Supreme Press from Brownells. It should be here in the next day or so. I ordered a set of carbide .45 LC dies and shell holder from Cheaper Than Dirt. I also ordered the 310 die adapter from MidwayUSA. 
