As a handgun hunter and advocate of the .45 Colt here is my considered opinion.
First, I'll back up Rocky and say you'll have a difficult time recovering bullets from critters when you are using hard cast in the .45 Colt, pretty well regardless of velocity (include .44 mag, et al, in that statement). I think I have maybe one. Yeah, now I remember. It went through several inches of neck bone in a bison, the entire skull, and was somewhat poking out the bone above one eye. I had the skull cleaned up and gave it to a friend whom I've hunted with and he quite appreciated the personal touch on that skull mount
Anyway, having said that, there are some things you can do to predict the ability of the gun to handle XXX pressure loadings ahead of time. Engineers do this all the time so they don't have to do destructive testing on EVERYTHING. Yeah they occasionally crash a mini-van into a barrier with test dummies to validate the work, but a lot of calculations went into that event. So.... if you carefully consider all of the dimensions of the "brand x" revolver, and evaluate the type of metals, production means, tolerances, etc., etc., then it is reasonable to suggest what pressures the gun SHOULD stand.
Even the mini-vaqueros (or whatever they are called) are slightly larger in dimensions than the original Colts, and WAY better materials and quality control. 20,000 psi? I don't doubt it.
50,000 (or whatever, I read the article too but don't have it handy anymore) in the Redhawk? Yeah, maybe. It has more metal around the cylinders, and the bolt notches are more offset than a Blackhawk. Admittedly, a very specialized loading that is confined to a few guns, but if Brian wants to do it, that's his business. I seriously doubt that Wolfe publications would print this if it were very dangerous.
Last..... doesn't matter what level the Redhawk will stand, as I don't ever intend to run above that. Even if I get one (which I'd like), I won't. For one, the muzzle blast at those pressures is unpleasant. That was one of the reasons I got rid of a nice .454 Casull. I am quite content at the 30,000-ish pressures that my handloads are running in my Bisleys and older Blackhawks and just don't intend to change. Mostly I don't even carry those loads as a 255gr. SWC at maybe 1,000fps is perfectly capable of what I need in a sidearm in the hunting fields.
I won't load a flat-top Ruger .45 Colt to 20,000 psi either, as frankly I don't plan on ever owning one. Just too concerned about the chance of a 30,000-ish load ending up in it. Plus recoil would be horrible.
That's my thoughts. In summary, I think Brian is credible or at least very close in his estimations on the guns mentioned above, but I already have my .45 Colt reloading at the level I am comfortable at, for the guns I have.