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Interesting thread. In my opinion killing results from the destruction of the CNS through a direct hit or indirectly by denying it oxygen via a rapid drop in blood pressure. The larger the surface area of a wound channel through the vitals, the more rapid the bleeding and hence the more rapid the onset of death. Bigger animals need larger wound channels with greater surface areas to achive critical losses of blood (and hence rapid blood pressure drops) than smaller animals, so generally a larger caliber is more effective. I don't believe energy has anything to do with killing effectiveness although factors that effect the creation of the wound channel do. All this assumes that correct shot placement is achieved on vital organs.
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