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My H&R shoots the 250gr. sized to .380 with 33grs of Re#7 the best. Use caution when reloading and follow your manual. I started at 28grs and worked up .5gr each time when it shot the 33grs. so well I never went any farther.hope this helps.............
 

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16 gr. of 5744 works for me, I have also loaded 9.5 gr. of Unique, 8.5 gr. of Red Dot, and 8.5 gr. of Power Pistol all with a ployester filler. The 5744 load shot the best but I am going to try some Trial Boss which should fill the case better.
 
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