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I use 280's in a Super Blackhawk but run full throttle with 296 (~1350fps). Probably not the best load for a Smith - I think that ID is on the right track.
265grs. at 1100fps should be a nice load, plenty powerful and a good step up from the .45 Super.
265grs. at 1100fps should be a nice load, plenty powerful and a good step up from the .45 Super.