Okay guys here is a question that I have been wondering about. I have a Ruger Bisley 45 Colt. I had John Gallagher (in Jasper, Alabama) open up the cylinder throats to 0.4525" and he did a Taylor throating on the forcing cone and tuned up the action and trigger. I had a 2x scope on earlier for load development and it shot many groups under 1.5" at 25 yards and even several under 1". It did seem that it preferred some powders and charge weights over others. However, I am wondering if it is really as critical in load tuning to get just the right amount of powder and type of powder. Certainly getting a good bullet fit is important (I am using 0.452" 250 RNFP bullets from Laser-Cast and Mid-Kansas for my light load). With the rifles that I am used to shooting choosing the right powder and then the exact amount (0.2 to 0.5 grains) can make a big difference in accuracy with a rifle due to barrel vibration harmonics. Is it realistic to think that with a revolver that one of these powders (231 or Titegroup or Universal Clays or Unique etc) would give better accuracy than any other? Then if for example Universal Clays was best is it likely that the gun would shoot smaller groups with 7.0 grains than it would with 6.8 or 7.2? Hopefully you get my drift here. Basically with a revolver do you all find that tuning the load is that big of a deal (choosing the optimum powder and amount) or so long as you have a proper bullet fit does the gun just shoot good with all kinds of different loads. Mainly I am referring to light loads. I know that H110/296 does best at top pressures. Thanks, Brian.