Marshall and all others with useful input, I have some questions about developing a maximum hunting load for my Ruger Bisley six shot 45 Colt. I have read your excellent article in the tech notes section and have a few points I would like clarification on. First question has to do with the use of H110 and the comment you made about how it performs best in the top 5% of the pressure envelope. This is somewhat confusing to me because that top 5% is different for a 6 gun versus a 5 gun. Does H110 perform best at 30,000 CUP or 40,000 CUP? The powder does not know if it is being used in a 5 shot or a 6 shot. Also I have heard it said that H110 does best with some compression from the seated bullet. The Cast Performance 335 has 0.45” of its bullet extending into the case. What powder charge would be required to get some compression? Next question has to do with the aspect of extreme spread. You said that as the max load is approached the ES should drop, very possibly into the single digits. I have yet to see this happen. I generally am getting ES figures in the 50 fps range. Is this a sure sign that I have not reached a safe max load yet? Finally I have a question regarding velocity. As previously posted I was getting some insanely high velocities from my load using H110 and the Cast Performance 335 grain bullet. 22.2 grains of H110 gave me 1500 fps. More likely the true velocity was about 1300 fps. 21.7 grains gave a velocity of 1470 fps and 22.7 grains gave 1540 fps. Extreme spread was from 30 to 60 fps. So since the velocity had not flatlined is it safe to assume that I could keep going up and up and up in powder charge until the velocity did flatline or does that only apply to 5 shot loads? I do not feel a need to change this load as it is plenty fast even if the actual velocity is only 1250 fps (in particular the 22.2 grain load as it gave a 2.0” group at 55 yards with open sights- my best ever even when I had a 2x scope attached) but am still curious about these things. Thanks, Brian Carlson.