I've shot lot's of coyotes with these, they are very reliable, you will lose very few. I use H335 in my 16"AR and BLC-2 in my 24" 700 both with CCI magnum primers. Both guns shoot very good in sub-zero temperatures. I aim to hit a shoulder going in or on the offside when possible, 75% time there is a small hole going in and no exit.
Another advantage to these is they have very little wind drift.