The 223 is rather effective on Deer with a proper bullet.
This thread is about nothing but Deer taken with the 223:
http://24hourcampfire.com/ubbthreads/ubbthreads.php/topics/4570370/1/223_Deer_Kill_Pics
Shot location is the most important and then the bullet.
I'd bet that a properly place 45 ACP bullet will most certainly stop a Couger pronto