Do you mean 4350?
Either IMR-4350 or Hodgdon 4350 are a bit on the slow side for the .338-06, and maximum charges will probably be compressed. Whether the starting charge is compressed or not would depend somewhat on the capacity of the individual brand of cases, and also how well the powder settles in the case as it is poured in.
You might try gently tapping the case as you pour the powder in to see if it settles a bit more.
A little powder compression will probably not hurt anything. Seat some bullets, carefully measure the overall length, and see if they 'grow' after 24 hours from the powder pushing against the base of the bullet. If not, I would not worry about it.
Do check your scale and make sure that you are really at the starting weights.