Yeah, the 22-250 is a great gun. But in the wind the 243 or 25-06 would be a good choice. I have both and would probably grab the 243 myself because there is definitely more loaded ammo to choose from. There's certainly quite a few choices with the 25-06 but really many more with the 243. The Winchester 85gr BT for the 25-06 is a pretty mean ole boy on coyotes, long range or short. I would personally get either one with at least a 24 inch barrel if not longer. The 25-06 for sure needs at least a 24 inch tube to better it's potential, anyway good luck to ya with whatever you decide on and let us know !