I have both the 22-250 and 243 and about 20 years ago I had a 25/06 Vanguard that I LOVED but someone borrowed it from my truck one night without asking! 
I carry my 22/250 on my farm for yotes, wandering dogs, beavers, muskrats etc... but I'm rarely taking shots over 300yds and especially not in "out west/Canadian prarie winds". If I were in your situation and could only have one of the 3 mentioned, I'd probably have to go with the 243! My boys have 2 of them and I must admit, it is a SWEET and very versatile caliber.
I carry my 22/250 on my farm for yotes, wandering dogs, beavers, muskrats etc... but I'm rarely taking shots over 300yds and especially not in "out west/Canadian prarie winds". If I were in your situation and could only have one of the 3 mentioned, I'd probably have to go with the 243! My boys have 2 of them and I must admit, it is a SWEET and very versatile caliber.
