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You would need to reduce your starting loads due to higher pressures generated with the magnum primers. I'm assuming that's all you can obtain is the magnum primers. Would be best served with regular primers if there available.
 

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It also depends on the maker. Remington 6 1/2 primers are a standard primer used in the 22 Hornet, 221 Fireball etc. The 7 1/2 says it's a Benchrest primer but is more of a mag primer for the .223.
 

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can small magnum rifle primers be substituted for small rilfe primers in the .223rem. poppa
Whenever you change a given component in your load recipe, especially if it varies from a specific book recipe, you always back off 10% and work back up. Even if you go from a magnum primer to a standard primer, you follow this logic. Primer/powder/load compression/crimp/bullet weight/bearing surface...there are too many variables to consistently predict what effect changing any of them is going to have on the resulting pressures.
 

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Take a look at the data you are using... it might be tested with Magnum primers...
 
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