I only have one, a blued 6". It is my favorite handgun and is deadly accurate. I've used it on deer and hogs, with 170 grain bullets and it works just fine. Every now and then I'll take it out and compare it to my Dan Wesson, Ruger and Smith and there really is no comparison, in my opinion at least. I do not abuse my guns and typically will shoot reduced loads for practice and only shoot full power loads for a reason, hunting or, in the past, silhouette. Some will say that a Python loosens up but mine has not.
I guess once you have one, shoot it and handle it, everything else seems slightly inferior. I know that there are other handguns but I must be biased. From the prices you see, alot of others are, too! It is probably in the "TOP 10" of collected handguns behind 1911s and SAA Colts!