When I was growing up in central Texas, 'yotes were not the only predators. We lived at the edge of town and had some chickens. I don't remember just what kind of dog it was getting our chickens; but he was big. Dad stood just inside the front room of the house, bracing a little Remington .22 on the door frame. He shot the dog with a .22 short at a distance of at least 50 yards. We heard the dog yelp just as he disappeared into some brush. Dad and I went to the spot and found the dog. He was only about 10 feet past where he was shot. He was dead, with a small entry hole on his right side, and a hole about the size of a cup on the other side with intestines hanging out. Yes, I believe a .22lr can kill a coyote.