I wouldn't hesitate for a second to hunt coyotes with a .22LR as long as I could get in a good shot. I suspect I'd try hollow points and go for lung or heart shots. They'd go a ways but would not last long. If you're close enough for 'ear' shots, solids or HP would do the job nicely and they'd drop like a rock. It's all a matter of shot placement. If you can get close enough on a stand with camo etc, you should be able to shoot inside a quarter coin with a Marlin 39 with a scope. Those things are incredibly accurate. I've killed squirrels at 50yds+ with mine with iron sights. They're pretty impressive on accuracy.