I have used Grand Slams in .270, 7X57, .280 Rem., and .30-06. I have killed deer and elk with them. I have recovered three or four bullets. None were overly impressive for their weight retention, but I never had a failure. Ranges varied from 30 yards to about 300 yds. I believe that Nosler partitions are tougher and will retain more weight, but the GS's worked every time.