Nominal ballistics for the 375 Ruger: 270 grn bullet, .375 diameter, MV @ 2840 fps.
Punched in the numbers and came up with 192 rating good enough for lion, leopard, grizz and brown bear.
Enter a 300 grain bullet @ 2660 fps (hottest load for that weight I have) and you get a rating of 200.
150 is minimum for the above mentioned critters. 250 rating is minimum suggested for elephant, Cape buffalo, hippopotamus or WalMart shoppers.
Of course, you would have to rework the numbers at the appropriate downrange maximum distance but I doubt your PH would allow you to take a shot at any of these over 100 yards...unless you're shooting a 50 BMG.
For grins I did the 50 BMG and it comes up with a rating of......................601! That's figuring a 700 grn Barnes @ 2900 fps
The 700 Hubel Express 3.25" rates a 963.......1000 grn bullet @ 2600 fps!