For me, handgun hunting is an up close and personal proposition. That is why I do it. It is more difficult. That said, I am not averse to taking shots over 100 yards and practice frequently with my revolvers well beyond the 100 yard mark. I know my .475 Linebaugh consistently and repeatably drops 18-inches at 200 yards, and I have it sighted in for 100 yards.
I have tested the XVR rather extensively and it is a really large and cumbersome revolver. The marketing behind the .460 caliber was brilliant and clear -- to have the fastest (highest velocity) revolver/cartridge combination available commercially. It achieves this bragging right in spades with lightweigh bullets. While they work really well on thin-skinned game, high-speed light bullets aren't the ticket for thicker-skinned game. With heavier bullets -- still at high speeds -- relatively speeking (395 grain WFNs at 1,525 fps), the performance on hogs I shot wasn't spectacular -- this of itself doesn't prove much of anything, but it didn't leave me with much confidence. By contrast, everything my .475 touches reacts almost predictably.
Now on to muzzle energy -- something that is calculated and not measured, is also a marketing tool and a poor way to compare and contrast cartridges. The .454 Casull has better "paper ballistics" than even the .500 Linebaugh, but the much vaunted Casull is much lower down on the food chain I can assure you.
Personally, if I was to get a .460, I would pick a good middle-weight bullet, somewhat north of 300 grains, and run it at moderate speeds -- so, if I stick to those criteria, I can make do with a .45 Colt and actually carry it on my hip.
One last issue worth mention (someone else touched upon his) is the noise created by the brake on the XVR -- holy smoke! You absolutely must wear hearing protection even in the field when hunting, or you will lose your hearing in short order.
Sorry for the long post, but I hope it helps.