Chief,
I've been getting excellent results from Accurate No.5. I'm not really hot-rodding these loads; I'm only trying to get about 1100-1200 fps, and 12gr of AA5 is right in that range. It got just over 1100 in the 4 5/8" SBH, and almost 1200 in my 6" 629. The great thing is, extreme spreads are in the neighborhood of 5-8 fps, SD is 2-3 fps, so it is highly consistent. The only other powder I've tried is 2400, which gave decent velocity but less consistency and accuracy. The way I shoot a handgun, I need all the help I can get with accuracy!
BTW, I've been getting great results with AA5 and cast bullets in my 30 caliber rifles, too.