I went out shooting today with my Ruger Bisley 45 Colt 6-gun. I was shooting the Cast Performance 335 with H110. 22.2 grains gave me 1160 fps, 23.0 gave 1230, 23.5 gave 1250 and 24.0 gave 1280 fps. It seems that my gun requires a lot of powder to get the velocity. I noticed in load swap that another fellow (powderstuffer) listed a load of 19.0 grains of 296 with the BT 340 in Starline brass with a WLP primer for a velocity of 1058 fps. Well I tried that bullet with the same case and primer but with 21.0 grains of H110 and got 1050 fps. He got 8 fps more velocity with 2 grains less powder (I have been told that H110 and 296 are identical). Is it likely that a lot to lot difference could account for 2 grains more powder required to achieve the same velocity or is it more likely that his gun is tighter in bc gap and so less of the powders gasses are wasted? With my current load using the CP 335 and 24.0 grains of H110 to get 1280 fps I do not know if I am overboard. Cases came out just fine and the velocity had not flatlined. Thanks for any input, Brian C.