My two favorite hunting bullets are the nosler partition, and the remington corelokt.
I like the partition A lot, It would be my bullet of choice for anything bigger than mule deer. I have never recovered a partition from an animal, and i have never had any over expansion, including a stem to stern pass through on a spike elk at 20 yards (225 gr. partition, .338 WM). Using the partition gives extra insurance that your bullet will reach the vitals from any angle, on any game. I am not advising bad shot angles, but sometimes your only FOLLOW UP SHOT may be a very poor angle, this type of situation is what led to the stem to stern shot mentioned above.
I like using corelokts at more moderate velocitys, I use them in my 30-30. IME the round nosed corelokts 150-170 gr. .30 cal bullets open up very well at around 2000 fps on deer. I have only recovered one bullet out of 8 on various bucks, and it penetrated 2 ribs, straight through both lungs, and lodged in the off hide, DRT, was about a 15 yard qaurtering shot, 150 gr corelokt, i didnt measure the recovered bullet but it was about as big around as a qaurter, looking much like the advertised "mushroom" on the box. All of my experience is within 50 yards, excluding a 120 yard spine shot. All of the wound channels have been straight, with no deflections at all, even when bone was hit. Lungs are always jelly, i attribute a lot of this to the corelokt, hard to imagine a more ideal bullet design for the 1800-2400fps velocity range.